As the most common type of renal cell carcinoma (RCC), the renal clear cell carcinoma (ccRCC) is highly malignant and insensitive to chemotherapy or radiotherapy.Although systemic immunotherapies have been successfully applied to ccRCC in recent years, screening for patients who can benefit most from these therapies is still essential and challengi
Detection of Macro-Aspartate Aminotransferase (AST) in an Asymptomatic Patient with Persistent Elevation of AST
The persistent increase of aspartate aminotransferase (AST) due to the presence of a macro-AST can confuse diagnostic or therapeutic decisions in many clinical situations.In this study, we report a case of isolated and persistent AST-elevation without any clinical sign 2014 dodge ram 1500 fender flares of dysfunction in organs such as the liver, sk
pH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer
Multidrug resistance (MDR) is one of the main reasons for tumor chemotherapy failure.Podophyllotoxin (PPT) has been reported that can suppress MDR cancer cell growth; however, effective delivery of PPT to MDR cancer cells is challenged by cascaded bio-barriers.To effectively deliver PPT to MDR cancer cells, a PPT polymeric prodrug micelle (PCDMA) w